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KMID : 1161420110140040386
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Journal of Medicinal Food
2011 Volume.14 No. 4 p.386 ~ p.390
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Effects of Coenzyme Q10 on Arterial Stiffness, Metabolic Parameters, and Fatigue in Obese Subjects: A Double-Blind Randomized Controlled Study
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Lee Yong-Jae
Cho Wan-Je
Kim Jong-Koo
Lee Duk-Chul
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Abstract
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This study investigated the effects of coenzyme Q10 supplementation on metabolic parameters, inflammatory markers, arterial stiffness, and fatigue in obese subjects. We performed a randomized, double-blind, placebo-controlled, single-center study on 51 obese subjects with a body mass index (BMI) of ≥25?kg/m2. Subjects were randomized into either a coenzyme Q10 (200?mg/day) group (n?=?26, BMI?=?27.9?±?2.3?kg/m2, age?=?42.7?±?11.3 years) or a placebo group (n?=?25, BMI?=?26.8?±?2.8?kg/m2, age?=?41.3?±?11.2 years) for a 12-week study. We collected anthropometric measurements, blood for laboratory testing, brachial?ankle pulse wave velocity (baPWV) as an indicator of arterial stiffness, and responses to a fatigue severity scale (FSS) questionnaire at the initial (0 week) and final (12 weeks) visits. A total of 36 subjects successfully completed the study protocol. Serum coenzyme Q10 levels increased significantly from 0.65?±?0.27?μg/mL to 1.20?±?0.38?μg/mL in the coenzyme Q10 group (P?
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KEYWORD
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coenzyme Q10, fatigue, obesity, randomized clinical trial
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